Naloxone Hydrochloride
Naloxone Hydrochloride is a pure opioid antagonist that acts as a competitive antagonist at mu, kappa, and delta opioid receptors, with the highest affinity for the mu receptor. It is used to rapidly reverse life-threatening respiratory depression caused by opioids.
Dosage by Body Weight
Administer immediately in cases of suspected opioid overdose. For nasal spray, spray once into one nostril. For injection, administer 0.4 mg to 2 mg IM, SC, or IV. Repeat doses every 2 to 3 minutes if the patient does not respond or relapses into respiratory depression.
- Body Weight
- Below 5 kg
- Dose
- 0.1 mg/kg
- Frequency
- Repeat every 2 to 3 minutes as needed
- Tracking Notes
- May be administered IV, IM, or SC. Ensure emergency medical services are called immediately.
- Body Weight
- 5-7 kg
- Dose
- 0.5 mg to 0.7 mg
- Frequency
- Repeat every 2 to 3 minutes as needed
- Tracking Notes
- Monitor breathing closely. Provide rescue breathing if trained.
- Body Weight
- 8-10 kg
- Dose
- 0.8 mg to 1.0 mg
- Frequency
- Repeat every 2 to 3 minutes as needed
- Tracking Notes
- Administer subsequent doses if there is no response or minimal response.
- Body Weight
- 11-15 kg
- Dose
- 1.1 mg to 1.5 mg
- Frequency
- Repeat every 2 to 3 minutes as needed
- Tracking Notes
- Standard adult doses may be used safely if weight-based calculations are not feasible.
- Body Weight
- 16-20 kg
- Dose
- 1.6 mg to 2.0 mg
- Frequency
- Repeat every 2 to 3 minutes as needed
- Tracking Notes
- A standard 2 mg dose is commonly administered to patients in this weight range.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.1 mg/kg | Repeat every 2 to 3 minutes as needed | May be administered IV, IM, or SC. Ensure emergency medical services are called immediately. |
| 5-7 kg | 0.5 mg to 0.7 mg | Repeat every 2 to 3 minutes as needed | Monitor breathing closely. Provide rescue breathing if trained. |
| 8-10 kg | 0.8 mg to 1.0 mg | Repeat every 2 to 3 minutes as needed | Administer subsequent doses if there is no response or minimal response. |
| 11-15 kg | 1.1 mg to 1.5 mg | Repeat every 2 to 3 minutes as needed | Standard adult doses may be used safely if weight-based calculations are not feasible. |
| 16-20 kg | 1.6 mg to 2.0 mg | Repeat every 2 to 3 minutes as needed | A standard 2 mg dose is commonly administered to patients in this weight range. |
Formulation
Purpose
Emergency treatment of known or suspected opioid overdose, characterized by respiratory and/or central nervous system depression.
Generic Name
Naloxone HydrochlorideBranded Drug Names
Naloxone Hydrochloride is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.